Michael J Clare-Salzler

Michael J Clare-Salzler, M.D.

Professor Emeritus

Department: MD-PATHOLOGY
Business Phone: (352) 339-3618
Business Email: salzler@ufl.edu

About Michael J Clare-Salzler

Michael J. Clare-Salzler, MD, is a professor of medicine who received his medical degree and internal medicine training from the State University of New York at Buffalo. He began his clinical endocrinology and immunology research career at the University of California in Los Angeles, where he studied the immunopathogenesis of type 1 diabetes. 

Dr. Clare-Salzler maintains an active practice in endocrinology, treating patients with diabetes and other endocrine diseases. 

Teaching Profile

Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
2008-2011
GMS6382 Special Topics in Immunology

Board Certifications

  • Endocrinology, Diabetes and Metabolism
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Pathology, Immunology and Laboratory Medicine
Areas of Interest
  • Diabetes
  • Diabetes diet – type 1
  • Diabetes education
  • Pheochromocytoma
  • Thyroid cancer
  • Thyroid diseases
  • Thyroid nodule
  • Type 1 diabetes
  • Type 2 diabetes

Publications

2023
CYP2D6-guided opioid therapy for adults with cancer pain: A randomized implementation clinical trial.
Pharmacotherapy. 43(12):1286-1296 [DOI] 10.1002/phar.2875. [PMID] 37698371.
2021
Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti-Citrullinated Protein Antibody-Positive Population.
Arthritis & rheumatology (Hoboken, N.J.). 73(6):955-962 [DOI] 10.1002/art.41631. [PMID] 33381911.
2021
Collection and Storage of Human Plasma for Measurement of Oxylipins.
Metabolites. 11(3) [DOI] 10.3390/metabo11030137. [PMID] 33652624.
2021
Pathology Informatics and Robotics Strategies for Improving Efficiency of COVID-19 Pooled Testing.
Academic pathology. 8 [DOI] 10.1177/23742895211020485. [PMID] 34189259.
2021
Predictors of oxylipins in a healthy pediatric population.
Pediatric research. 89(6):1530-1540 [DOI] 10.1038/s41390-020-1084-2. [PMID] 32726799.
2021
The Hologic Aptima SARS-CoV-2 assay enables high ratio pooling saving reagents and improving turnaround time.
Journal of clinical laboratory analysis. 35(9) [DOI] 10.1002/jcla.23888. [PMID] 34213803.
2021
The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).
Diabetologia. 64(8):1785-1794 [DOI] 10.1007/s00125-021-05457-9. [PMID] 33893822.
2020
Informatics Training for Pathology Practice and Research in the Digital Era.
Academic pathology. 7 [DOI] 10.1177/2374289520911179. [PMID] 32284963.
2020
Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.
JAMIA open. 3(4):523-529 [DOI] 10.1093/jamiaopen/ooaa055. [PMID] 33754137.
2019
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genetics in medicine : official journal of the American College of Medical Genetics. 21(8):1842-1850 [DOI] 10.1038/s41436-018-0431-8. [PMID] 30670877.
2019
Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.
ACS biomaterials science & engineering. 5(5):2631-2646 [DOI] 10.1021/acsbiomaterials.9b00332. [PMID] 31119191.
2019
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes.
Nutrients. 11(9) [DOI] 10.3390/nu11092185. [PMID] 31514368.
2019
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Nature. 574(7777):187-192 [DOI] 10.1038/s41586-019-1629-x. [PMID] 31597973.
2019
Vitamin D and Omega 3 Field Study on Progression of Type 1 Diabetes.
CellR4– repair, replacement, regeneration, & reprogramming. 7 [DOI] 10.32113/cellr4_20198_2737. [PMID] 31572748.
2018
Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.
Contemporary clinical trials. 68:7-13 [DOI] 10.1016/j.cct.2018.03.001. [PMID] 29535047.
2018
Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection.
Clinical immunology (Orlando, Fla.). 195:139-148 [DOI] 10.1016/j.clim.2018.06.003. [PMID] 29894743.
2018
Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice.
Journal of immunology research. 2018 [DOI] 10.1155/2018/5463879. [PMID] 29651443.
2018
Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.
Clinical and translational science. 11(2):175-181 [DOI] 10.1111/cts.12533. [PMID] 29351371.
2018
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions. 11(2):181-191 [DOI] 10.1016/j.jcin.2017.07.022. [PMID] 29102571.
2017
Enrichment of IL-17A+ IFN-γ+ and IL-22+ IFN-γ+ T cell subsets is associated with reduction of NKp44+ ILC3s in the terminal ileum of Crohn’s disease patients.
Clinical and experimental immunology. 190(1):143-153 [DOI] 10.1111/cei.12996. [PMID] 28586085.
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics. 18(5):421-426 [DOI] 10.2217/pgs-2017-0028. [PMID] 28346068.
2017
Macrophage integrins modulate response to ultra-high molecular weight polyethylene particles and direct particle-induced osteolysis.
Biomaterials. 115:128-140 [DOI] 10.1016/j.biomaterials.2016.10.038. [PMID] 27889664.
2017
Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis.
Annals of the rheumatic diseases. 76(1):147-152 [DOI] 10.1136/annrheumdis-2016-209154. [PMID] 27190099.
2017
The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population.
Rheumatology (Oxford, England). 56(12):2229-2236 [DOI] 10.1093/rheumatology/kex360. [PMID] 29029330.
2017
Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas.
EBioMedicine. 22:10-17 [DOI] 10.1016/j.ebiom.2017.06.014. [PMID] 28663145.
2017
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.
Diabetes. 66(12):3061-3071 [DOI] 10.2337/db17-0106. [PMID] 28877912.
2016
A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation.
Journal of materials chemistry. B. 4(9):1672-1685 [PMID] 26985393.
2016
Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria.
Chemistry (Weinheim an der Bergstrasse, Germany). 22(24):8158-66 [DOI] 10.1002/chem.201600674. [PMID] 27139508.
2016
Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study.
Rheumatology (Oxford, England). 55(2):367-76 [DOI] 10.1093/rheumatology/kev266. [PMID] 26370400.
2016
Micro and Nano Material Carriers for Immunomodulation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(12):3362-3370 [DOI] 10.1111/ajt.13878. [PMID] 27214679.
2016
Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens.
International immunopharmacology. 31:158-68 [DOI] 10.1016/j.intimp.2015.12.023. [PMID] 26735611.
2016
Restoring immune tolerance in neuromyelitis optica: Part I.
Neurology(R) neuroimmunology & neuroinflammation. 3(5) [DOI] 10.1212/NXI.0000000000000276. [PMID] 27648463.
2016
Restoring immune tolerance in neuromyelitis optica: Part II.
Neurology(R) neuroimmunology & neuroinflammation. 3(5) [DOI] 10.1212/NXI.0000000000000277. [PMID] 27648464.
2016
Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis.
BMJ open diabetes research & care. 4(1) [DOI] 10.1136/bmjdrc-2016-000260. [PMID] 27651910.
2015
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.
Clinical immunology (Orlando, Fla.). 160(1):90-102 [DOI] 10.1016/j.clim.2015.03.023. [PMID] 25842187.
2015
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.
Genetics & epigenetics. 7:5-17 [DOI] 10.4137/GEG.S29696. [PMID] 26512207.
2015
Current concepts on the pathogenesis of type 1 diabetes–considerations for attempts to prevent and reverse the disease.
Diabetes care. 38(6):979-88 [DOI] 10.2337/dc15-0144. [PMID] 25998290.
2015
Effect of docosahexaenoic acid supplementation on inflammatory cytokine levels in infants at high genetic risk for type 1 diabetes.
Pediatric diabetes. 16(4):271-9 [DOI] 10.1111/pedi.12170. [PMID] 25039804.
2015
Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.
Current diabetes reports. 15(11) [DOI] 10.1007/s11892-015-0656-8. [PMID] 26385483.
2014
Anti-CD3 antibody treatment induces hypoglycemia and super tolerance to glucose challenge in mice through enhancing glucose consumption by activated lymphocytes.
Journal of immunology research. 2014 [DOI] 10.1155/2014/326708. [PMID] 24741590.
2014
C-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0097694. [PMID] 24835010.
2014
Characterization of Bone Marrow-Derived Dendritic Cells Developed in Serum-Free Media and their Ability to Prevent Type 1 Diabetes in Nonobese Diabetic Mice.
Journal of blood disorders & transfusion. 5(4) [PMID] 26779386.
2014
Clinical pharmacogenetics implementation: approaches, successes, and challenges.
American journal of medical genetics. Part C, Seminars in medical genetics. 166C(1):56-67 [DOI] 10.1002/ajmg.c.31390. [PMID] 24616371.
2014
Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.
Journal of materials chemistry. B. 2(17):2562-2574 [PMID] 24778809.
2014
Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young.
Diabetologia. 57(2):295-304 [DOI] 10.1007/s00125-013-3106-7. [PMID] 24240437.
2014
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950). 193(3):1024-34 [DOI] 10.4049/jimmunol.1303230. [PMID] 24973447.
2014
Infection and persistence of erythrovirus B19 in benign and cancerous thyroid tissues.
Journal of medical virology. 86(9):1614-20 [DOI] 10.1002/jmv.23852. [PMID] 24265024.
2014
Integrin-directed modulation of macrophage responses to biomaterials.
Biomaterials. 35(11):3504-15 [DOI] 10.1016/j.biomaterials.2014.01.007. [PMID] 24462356.
2014
It’s time to bring dendritic cell therapy to type 1 diabetes.
Diabetes. 63(1):20-30 [DOI] 10.2337/db13-0886. [PMID] 24357690.
2013
Anti-lymphocyte antibody-based immunotherapy in type 1 diabetes.
Chinese medical journal. 126(5):957-64 [PMID] 23489809.
2013
Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(7):1126-9 [DOI] 10.1016/j.bbmt.2013.04.011. [PMID] 23611977.
2013
Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.
Pharmacogenomics. 14(7):723-6 [DOI] 10.2217/pgs.13.59. [PMID] 23651020.
2013
Omega-3 Supplement Use Is Associated With a Reduced Risk of Anti-Cyclic Citrullinated Protein Positivity in a Population Without Rheumatoid Arthritis, But At Risk for Future Disease
Arthritis and Rheumatism. 65
2013
Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076919. [PMID] 24204704.
2013
The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.
Clinical pharmacology and therapeutics. 94(2):207-10 [DOI] 10.1038/clpt.2013.59. [PMID] 23588301.
2012
Anti-Thymocyte Globulin (Atg) Differentially Depletes Naive and Memory T Cells and Permits Memory-Type Regulatory T Cells
Blood. 120
2012
Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.
BMC immunology. 13 [DOI] 10.1186/1471-2172-13-70. [PMID] 23237483.
2012
Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array.
Clinical pharmacology and therapeutics. 92(4):437-9 [DOI] 10.1038/clpt.2012.125. [PMID] 22910441.
2012
Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation.
Transplant infectious disease : an official journal of the Transplantation Society. 14(6):618-25 [DOI] 10.1111/j.1399-3062.2012.00750.x. [PMID] 22672201.
2012
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.
PloS one. 7(5) [DOI] 10.1371/journal.pone.0036079. [PMID] 22615750.
2012
Total synthesis of grassystatin A, a probe for cathepsin E function.
Bioorganic & medicinal chemistry. 20(15):4774-80 [DOI] 10.1016/j.bmc.2012.05.077. [PMID] 22748705.
2011
Adhesive substrates modulate the activation and stimulatory capacity of non-obese diabetic mouse-derived dendritic cells.
Acta biomaterialia. 7(1):180-92 [DOI] 10.1016/j.actbio.2010.08.026. [PMID] 20807596.
2011
Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).
Pediatric diabetes. 12(8):669-75 [DOI] 10.1111/j.1399-5448.2011.00760.x. [PMID] 21435137.
2011
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes.
Human vaccines. 7(1):37-44 [PMID] 21157186.
2011
Parvovirus B19 infection in Hashimoto’s thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association. 21(4):411-7 [DOI] 10.1089/thy.2010.0307. [PMID] 21190433.
2011
Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.
Diabetes. 60(10):2566-70 [DOI] 10.2337/db11-0576. [PMID] 21844098.
2011
University of Florida Clinical and Translational Science Institute: transformation and translation in personalized medicine.
Clinical and translational science. 4(6):400-2 [DOI] 10.1111/j.1752-8062.2011.00348.x. [PMID] 22212220.
2010
Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipients.
Transplantation. 89(1):115-23 [DOI] 10.1097/TP.0b013e3181bc6096. [PMID] 20061927.
2010
Erythrocyte membrane fatty acid content in infants consuming formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): an observational study.
Maternal & child nutrition. 6(4):338-46 [DOI] 10.1111/j.1740-8709.2009.00230.x. [PMID] 21050388.
2010
Experimental extracorporeal photopheresis therapy significantly delays the development of diabetes in non-obese diabetic mice.
Clinical immunology (Orlando, Fla.). 135(3):374-83 [DOI] 10.1016/j.clim.2010.01.018. [PMID] 20223712.
2010
Hyper-responsive phenotype in localized aggressive periodontitis.
Journal of dental research. 89(2):143-8 [DOI] 10.1177/0022034509353397. [PMID] 20042739.
2010
The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates.
Biomaterials. 31(29):7444-54 [DOI] 10.1016/j.biomaterials.2010.06.025. [PMID] 20637504.
2009
A high-throughput microparticle microarray platform for dendritic cell-targeting vaccines.
Biomaterials. 30(25):4168-77 [DOI] 10.1016/j.biomaterials.2009.04.032. [PMID] 19477505.
2009
Anti-Mouse Thymocyte Globulin Administration Alters Dendritic Cell Profile and Function in Nod Mice To Suppress Diabetogenic Responses.
American Journal of Transplantation. 9
2009
Dendritic Cell Therapy for Prevention of Type 1 Diabetes: Role of Peptide Presentation On Immune Modulation
Clinical Immunology. 131 [DOI] 10.1016/j.clim.2009.03.159.
2009
Extracorporeal photopheresis-induced immune tolerance: a focus on modulation of antigen-presenting cells and induction of regulatory T cells by apoptotic cells.
Current opinion in organ transplantation. 14(4):338-43 [DOI] 10.1097/MOT.0b013e32832ce943. [PMID] 19444106.
2009
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950). 182(8):4608-15 [DOI] 10.4049/jimmunol.0713269. [PMID] 19342635.
2008
Adhesive substrate-modulation of adaptive immune responses.
Biomaterials. 29(36):4736-50 [DOI] 10.1016/j.biomaterials.2008.08.040. [PMID] 18829103.
2008
Apoptotic non-beta cells suppress beta cell antigen-reactive T cells and induce beta cell antigen-specific regulatory T cells.
Annals of the New York Academy of Sciences. 1150:167-70 [DOI] 10.1196/annals.1447.038. [PMID] 19120288.
2008
Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children.
European journal of clinical nutrition. 62(6):733-8 [PMID] 17440518.
2008
Infusion of UVB-treated splenic stromal cells induces suppression of beta cell antigen-specific T cell responses in NOD mice.
Journal of autoimmunity. 30(4):283-92 [DOI] 10.1016/j.jaut.2007.11.017. [PMID] 18226498.
2008
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes. 57(2):405-14 [PMID] 18039815.
2007
Dendritic cells post-maturation are reprogrammed with heightened IFN-gamma and IL-10.
Biochemical and biophysical research communications. 352(4):960-5 [PMID] 17157804.
2007
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine. 204(6):1463-74 [PMID] 17548519.
2007
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
Diabetes. 56(3):604-12 [PMID] 17327427.
2007
Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes.
JAMA. 298(12):1420-8 [PMID] 17895458.
2007
Transfusion of apoptotic beta-cells induces immune tolerance to beta-cell antigens and prevents type 1 diabetes in NOD mice.
Diabetes. 56(8):2116-23 [PMID] 17496235.
2007
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood. 110(10):3673-81 [PMID] 17690255.
2007
Truncated pStat5B is associated with the Idd4 locus in NOD mice.
Biochemical and biophysical research communications. 356(3):655-61 [PMID] 17382905.
2007
Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.
Journal of immunology (Baltimore, Md. : 1950). 178(6):3886-92 [PMID] 17339488.
2006
Dendritic cell subsets and type I diabetes: focus upon DC-based therapy.
Autoimmunity reviews. 5(6):419-23 [PMID] 16890897.
2006
Eicosanoid imbalance in the NOD mouse is related to a dysregulation in soluble epoxide hydrolase and 15-PGDH expression.
Annals of the New York Academy of Sciences. 1079:130-4 [PMID] 17130543.
2006
Heightened interferon-alpha/beta response causes myeloid cell dysfunction and promotes T1D pathogenesis in NOD mice.
Annals of the New York Academy of Sciences. 1079:99-102 [PMID] 17130537.
2006
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes. 55(1):171-8 [PMID] 16380490.
2006
Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetes.
Annals of the New York Academy of Sciences. 1079:153-6 [PMID] 17130547.
2006
Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesis.
Annals of the New York Academy of Sciences. 1079:198-204 [PMID] 17130555.
2005
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 175(5):3282-6 [PMID] 16116220.
2005
Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity.
Scandinavian journal of immunology. 62(1):45-54 [PMID] 16091124.
2005
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology. 78(4):888-97 [PMID] 16033815.
2005
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.
Diabetes. 54(5):1407-14 [PMID] 15855327.
2005
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.). 23(6):507-15 [PMID] 15897802.
2005
In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases.
Scandinavian journal of immunology. 61(4):309-15 [PMID] 15853912.
2005
Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.
Journal of immunology (Baltimore, Md. : 1950). 175(7):4561-5 [PMID] 16177100.
2005
Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages.
Journal of autoimmunity. 24(4):297-310 [PMID] 15927792.
2005
The effects of renal transplantation on circulating precursor dendritic cells.
Transplantation proceedings. 37(1):3-6 [PMID] 15808527.
2005
The effects of renal transplantation on peripheral blood dendritic cells.
Clinical transplantation. 19(5):659-67 [PMID] 16146559.
2004
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 173(5):3035-43 [PMID] 15322163.
2004
IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes.
Journal of autoimmunity. 22(3):227-33 [PMID] 15041043.
2004
Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus–a new surrogate measure of non-progression?
Pediatric Diabetes. 5(2):72-9 [DOI] 10.1111/j.1399-543X.2004.00047.x. [PMID] 15189492.
2003
Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
Pediatric diabetes. 4(1):10-8 [PMID] 14655518.
2003
Abnormal peripheral blood dendritic cell populations in type 1 diabetes.
Annals of the New York Academy of Sciences. 1005:222-5 [PMID] 14679064.
2003
CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity. 71(11):6582-90 [PMID] 14573680.
2003
Defective maturation of myeloid dendritic cell (DC) in NOD mice is controlled by IDD10/17/18.
Annals of the New York Academy of Sciences. 1005:184-6 [PMID] 14679056.
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). 171(5):2270-8 [PMID] 12928371.
2002
Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes.
Annals of the New York Academy of Sciences. 958:160-2 [PMID] 12021097.
2002
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950). 168(7):3412-8 [PMID] 11907099.
2002
Indomethacin, dexamethasone, and intestinal damage in infant rats.
Journal of pediatric gastroenterology and nutrition. 35(2):154-61 [PMID] 12187290.
2001
Apoptosis in sepsis: a new target for therapeutic exploration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(6):879-92 [PMID] 11292647.
2001
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America. 98(20):11503-8 [PMID] 11553765.
2000
Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production.
Journal of immunology (Baltimore, Md. : 1950). 165(8):4298-304 [PMID] 11035064.
2000
Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.
American journal of physiology. Regulatory, integrative and comparative physiology. 278(4):R1005-18 [PMID] 10749790.
2000
Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of immunology (Baltimore, Md. : 1950). 165(11):6559-67 [PMID] 11086099.
1999
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation. 104(4):515-23 [PMID] 10449443.
1999
Caspase-3-dependent organ apoptosis early after burn injury.
Annals of surgery. 229(6):851-8; discussion 858 [PMID] 10363899.
1999
No alteration in T lymphocyte expression of CD40 ligand (CD154) in individuals with or at increased risk for insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism. 84(11):4068-72 [PMID] 10566651.
1998
Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950). 160(8):4082-9 [PMID] 9558119.
1998
Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.
Journal of applied physiology (Bethesda, Md. : 1985). 84(4):1119-30 [PMID] 9516174.
1997
Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Journal of immunology (Baltimore, Md. : 1950). 158(1):414-9 [PMID] 8977217.
1997
Systemic infection of mice by wild-type but not Spv- Salmonella typhimurium is enhanced by neutralization of gamma interferon and tumor necrosis factor alpha.
Infection and immunity. 65(12):5191-7 [PMID] 9393815.
1996
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nature medicine. 2(12):1348-53 [PMID] 8946834.
1996
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
The Journal of experimental medicine. 183(4):1561-7 [PMID] 8666914.
1995
Down-regulation of blood-brain glucose transport in the hyperglycemic nonobese diabetic mouse.
Neurochemical research. 20(7):869-73 [PMID] 7477681.
1995
Essential fatty acid deficiency prevents autoimmune diabetes in nonobese diabetic mice through a positive impact on antigen-presenting cells and Th2 lymphocytes.
Pancreas. 11(1):26-37 [PMID] 7667243.
1995
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
The Journal of clinical investigation. 95(2):628-34 [PMID] 7860747.
1994
Effect of H-2 compatibility in autoimmune destruction of islet allografts from B10 congenic lines to nonobese diabetic mice.
Pancreas. 9(2):179-85 [PMID] 8190719.
1993
Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.
The Journal of experimental medicine. 178(5):1675-80 [PMID] 8228814.
1993
Permanent diabetes developing after transient neonatal diabetes.
Lancet (London, England). 341(8852) [PMID] 8096989.
1993
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Nature. 366(6450):69-72 [PMID] 7694152.
1992
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
The Journal of clinical investigation. 89(1):283-92 [PMID] 1370298.
1992
Glutamate decarboxylase: an autoantigen in IDDM.
Diabetes care. 15(1):132-5 [PMID] 1737532.
1992
Marked dendritic cell-T cell cluster formation in the pancreatic lymph node of the non-obese diabetic mouse.
Immunology. 76(3):478-84 [PMID] 1356097.
1992
Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.
Diabetes care. 15(10):1273-6 [PMID] 1425088.
1992
Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.
The Journal of clinical investigation. 90(3):741-8 [PMID] 1522229.
1991
Endocardial metastases of follicular thyroid carcinoma: a case report and review of the literature.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 17(2):219-23 [PMID] 2015925.
1991
Thyroid function abnormalities associated with the chronic outpatient administration of recombinant interleukin-2 and recombinant interferon-alpha.
Journal of immunotherapy : official journal of the Society for Biological Therapy. 10(6):448-55 [PMID] 1768679.
1990
Destruction of islet isografts by severe nonspecific inflammation.
Transplantation proceedings. 22(2):855-6 [PMID] 2109420.
1990
Prolongation of islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-LYT2 monoclonal antibodies.
Transplantation proceedings. 22(2):880-1 [PMID] 2109427.
1989
Fetal pancreas transplantation in miniature swine. II. Survival of fetal pig pancreas allografts cultured at room temperature.
Diabetes. 38 Suppl 1:213-6 [PMID] 2642849.
1989
Islet transplantation for the cure of diabetes.
Pancreas. 4(1):123-35 [PMID] 2497459.

Grants

Sep 2018 – Jun 2023
A 3D Tissue Map of the Human Lymphatic System
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jun 2013 – Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
May 2013 – Jun 2018
Immune Function and the Progression to Type 1 Diabetes
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Sep 2012 – Aug 2016
The JDRF nPOD Viral Work Group: nPOD V
Role: Project Manager
Funding: JDRF
Jan 2012 – Mar 2017
Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery ofInsulin Peptide, Vitamin D3, TGF-b1 and GM-CSF for Type-1 Diabetes
Role: Project Manager
Funding: NATL INST OF HLTH
Jan 2010 – Jan 2021
UFFChandler Stetson Professorship Experimental Pathology
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2006 – Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Education

Other Program – Endocrinology, Diabetes and Metabolism
1988 · University of California, Los Angeles
Residency – Internal Medicine
1982 · State University of New York
Internship- Internal Medicine
1980 · State University of New York
Medical Degree
1979 · SUNY at Buffalo

Contact Details

Phones:
Business:
(352) 339-3618
Emails:
Business:
salzler@ufl.edu
Addresses:
Business Mailing:
PO Box 100275
GAINESVILLE FL 32610
Business Street:
M649
GAINESVILLE FL 326110001